Stem Cell Therapy for Cerebral Palsy
Wu Medical Center, Bejing, China
Infantile cerebral paralysis (young child brain paralysis) refers to non-progressive brain injuries which occur during the perinatal period.
Cerebral paralysis involves centrokinetic disorders resulting in abnormal posture, and may be accompanied by cognitive developmental disorders, epilepsy, dystrophy or disturbance of perception, language barriers and so on. Most patients present symptoms up to age one. Infantile cerebral paralysis is one kind of common disease occurring during infancy which is crippling and serious. Its incidence rate is approximately 1.5/ 1000 — 5/1000 . There is the largest number proportion in the young child nerve and genetic counseling outpatient service.
Brain paralysis characteristics and classification:
Growth: Refers to the damage the brain receives during the development and growth process.
Non-progressive: The pathological change is non-progressive, so the brain damage does not change with time and the symptoms don’t generally worsen.
Permanence: The brain paralysis is not a procedural disease, but results in a permanent barrier to the main central movement function.
Medical record abstract and treatment process: The patient is an 8 year old girl whose mother experienced dystocia when the girl was born. The doctor used obstetric forceps to help with the delivery. The girl was born with a serious oxygen deficit. Because of the doctor’s vigilant response, the girl was no longer in a life threatening position. A scan showed consistency with ischemia anoxic brain illness. The girl was presented with paralysis in all four limbs and epilepsy, the type of paroxysm and medication is unclear. The girl has received hyperbaric oxygen therapy and botulinum toxin therapy. The patient’s family members went to the hospital many times to help improve her cognition functioning and activity in her four limbs. Soon after, the patient’s gaze improved, there was slight autonomic activity in all four limbs, and she was able to respond to some simple questions, as well as displaying some simple emotional responses. The patient’s spirit is weak, unsatisfactory mood, very thin.
Temperature: 36.8, Bp96/55 mmHg, height: 106cm, weight: 13kg. The patient was presented with dysplasia. Her nutritional intake was poor, scissors gait, touchdown with toe, bilateral flat foot, chest growth symmetrical, no sign of rales in the lungs, the heart was in good condition, and the abdominal muscles were tight, with no knotting present.
Nervous System PE: Level of consciousness was ok, while content of consciousness was poor. She could not coordinate her memory, calculation skills or orientation. She had poor vocal quality, bilateral pupils are equal and round, and diameter is about 3.0mm. She had normal response to light. The movement of both eyes does not show obvious signs of nystagmus, but movement was not coordinated. The grains in the forehead were symmetrical, bilateral haso-liabial groove was equal depth and so on, her facial expressions were normal. The movement of her neck and four limbs was ok and there were no obvious signs of paralysis of her extremities, bilateral abdominal reflexes could not be induced by examination. Both lower limb pathological reflexes were negative. She could not cooperate with the medical examination to show her teeth and loll, four extremity myodynamias and muscle tone, tendon reflexes of the four limbs, sensory system and coordinate movements.
Treatment: Focus on improving circulation, administer anti-epilepsy medication, stem cells implantation (4 stem cell injections), nutritious stem cell cocktail treatment. Coordinate with special individual recovery training. The expected outcome was to improve the nerve function (movement function, optic nerve function and so on) and to control the epilepsy.
After the treatment: Patient had seen several significant improvements in her condition, height: 114cm, weight: 15.5kg. Her spirit was good, emotional responses were good. Her behavior and ability to express herself were much improved. Her vocal sounds were louder. Her eyes were more flexible, coordination was good, no obvious signs of nystagmus. The movement in the tip of the tongue was flexible and could stretch outside the lips. She had more control over the movement in her neck. Both hands can grasp lightly, but the capacity to hold things was poor. Both hands present normal function position. Both lower limbs had more myo-volume. She had normal arching of her feet and could stand with both soles grounded completely. She could take a step and the strength of her waist was improved. She could sit alone for approximately ten minutes with her legs crossed and with both elbows supported on a pillow. The muscle tone in all four limbs was not high. She had no epileptic seizures. The patient left the hospital two months later and her family members told us that her height and weight had reached normal levels. She can stand up and walk more than ten steps with someone assisting her.
Discussion: The patient was diagnosed with brain paralysis. The cause of her disease was clear; the stem cell treatment was effective. After the transplantation of neural stem cells which differentiated into nerve cells and through auto-activation of the baby’s brain and spinal cord’s own stem cells, there was an increase in the number of nerve cells in the central nervous system, to help repair the damaged neurons. In addition, we gave the patient physical and chemical induction therapy to promote the nerve stem cells in the brain to organize and differentiate, in order to have proper function, restore the cranial nerves’ normal growth, improve cerebrum cognition and movement function, and to provide more healing opportunities for the patient. Stem cell treatment is currently the most effective method and the younger the patient is, the better the chances of success. If the patient participates in the standard system’s recovery exercises after the nerve stem cell treatment, this will promote the growth of the nerve stem cells and assist the repairing function of these stem cells and as a result, the effect will be better. The intervention and treatment should begin as soon as possible, which is the only way to prevent brain paralysis, which has crippling effects. During the treatment process, the stem cells improve the patient’s cerebrum cognition and movement function. If the patient persists with the rehabilitation training, the improvements will continue.
by Drs. Sherry Xi, Xiaojuan Wang and Like Wu