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Also called: Alzheimer's disease (AD) is the most common form of dementia among older people. Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. AD usually begins after age 60. The risk goes up as you get older. Your risk is also higher if a family member has had the disease. Alzheimer's disease is an incurable, degenerative, eventually fatal disease that attacks cognitive function. It affects more than 26 million people around the world and is the most common form of dementia among people over the age of 65. Over the last three decades, most Alzheimer's research has been governed by the "amyloid cascade hypothesis.