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About ALS

Amyotrophic lateral sclerosis (ALS) is an incurable, degenerative neurological disease and its morbidity is about 5-8 people in every 100,000. Most of the patients developed the symptoms when their age reached over forty. The patient would begin to present weak symptoms and with their age increasing, the morbidity increased as well. Some ALS patients also developed dementia and Parkinson's disease.

The most common symptoms seen in ALS patients are when one of the side fingers has an awkward fine motor, stiff fingers and/or mild weakness of hand and muscles atrophy of hand. Then the disease progresses gradually after the first symptom. The patient will then suffer from weakness in the upper limbs and lower limbs, slurred speech, swallowing difficulty and breathing difficulty. The patient could also present signs of Parkinson’s disease and other neurodegenerative diseases. Regardless of the occurring pattern and developmental way of the disease, the disease progressed inexorably. More than half of the patients lost the ability of activity in the three years after the onset of the disease. The patients suffered from respiratory failure and the ability to swallow became difficult. 90% of the patients lost motor function completely within 6 years. The patients suffered from respiratory failure and circulatory failure and failure of other various organs. The pathology of ALS: the disease mainly damages the upper and lower motor neurons, anterior horn of the spinal cord, brainstem motor nuclei and the upper and lower part of the neuron in the cerebral cortex. Generally, the large nerve cells were shown to be damaged early on. After the cells disappeared, they were replaced by astrocytes and microglia cells. So, there were often no abnormal changes in the early MRI's.

Treating ALS With Stem Cells

There is no specific treatment plan for any type of motor neuron disease; there is only a type of supportive treatment. Current progress: With the development of biotechnology, using cell technology to control the ALS disease is developing too. Stem cells have the ability to continuously divide and differentiate into a number of different types of cell. Stem cells also secrete various cytokines, chemokines, and trophic factors that are known to modulate inflammation, attract other stem cells to sites of injury, enhance cell survival, and participate in angiogenesis and neurogenesis 
Wu Stems Cell Medical Center found that:

1. Cells have a good therapeutic reaction to such diseases

2. ALS has specific characteristics, such as nerve demyelination and gliocyte replaced and proliferative. This provides basis for targeting a location.

3. ALS patients are generally seen to have motor neuron loss of lamina propria, which provides anatomy bracket for stem cell. At the same time, this supports both cells homing differentiation.

We believe that drug control and physical training play an important role in cell repair for patients will ASL undergoing treatment.